Testosterone therapy inhibits endogenous testosterone production through negative feedback inhibition of luteinizing hormone (LH) levels. This suppresses follicle stimulating hormone (FSH) levels, which leads to azoospermia, the suppression of sperm production. Testosterone therapy can and likely will shrink your testicles, potentially interfering with fertility. As exogenous testosterone inhibits the HPTA, the pituitary stops receiving signals from the hypothalamus and stops producing LH which causes ITT levels to plummet. As ITT levels drop, sperm count decreases rapidly.
There are two methods to accomplish maintained ITT levels. Human chorionic gonadotropin (hCG) can be injected, which replaces LH as a near-perfect mimic of the LH that is normally produced by the pituitary. hCG will directly stimulate the Leydig cells to produce testosterone, keeping ITT levels high and driving sperm production. In some men, this is enough. Others require additional FSH to optimize the testes' environment for sperm production. FSH supplementation can be met via SERMs or Human Menopausal Gonadotropin (hMG).
hCG will also provide your testicles with an increase in size or fullness.
Gonadorelin is a gonadotropin-releasing hormone (GnRH) agonist commonly used in fertility medicine and to treat amenorrhea and hypogonadism. Gonadorelin is a form of the endogenous GnRH; bioidentical to GnRH's chemical structure.
Gonadorelin has even been shown reverse azoospermia in patients who've previously experienced suppression of sperm production.
Gonadorelin protects fertility and endogenous testosterone production which keeps you happy, healthy, and functional.
Modern medicine is incredible. But we always recommend patients freeze sperm to be used at a later date.
The risks of becoming permanently infertile from testosterone therapy are extremely low when taking precautionary measures. However, freezing your sperm is the best possible insurance policy against infertility.
Our free assessment quantifies your symptoms to see if hormone therapy is right for you. We're here to help you feel the way you want to feel.