Aging is characterized by physiological decline, causing impaired function and increased vulnerability to death. We can delay and reverse this decline with treatment and exercise.
Rapamycin and Metformin are both powerful medications with significant benefits for longevity and anti-aging.
Rapamycin
Originally used for preventing organ transplant rejection, Rapamycin has shown promise in extending lifespan and improving healthspan. It works by inhibiting the mTOR pathway, which is involved in cell growth and metabolism, helping to delay age-related diseases and maintain cellular health.
Rapamycin also activates the AMPK enzyme, which prompts the cell to conserve energy, seek alternative sources of energy, and release energy from fat cells.
Metformin
Primarily used for managing type 2 diabetes, Metformin has benefits for treating metabolic dysfunction. It improves insulin sensitivity, reducing the amount of sugar your liver releases and your body absorbs, leading to better metabolic function and lowering the risk of various health issues.
Metformin is typically taken in capsule form, providing a convenient and effective way to support your metabolic health.
What is mTOR?
It's the intracellular protein complex named mechanistic target of rapamycin. mTOR is like the general contractor for the cell. It tells the cell to switch between "growth" mode and "recycling" mode.
When nutrients are scarce, mTOR is suppressed, triggering cells to recycle components and clean up. Cell division, growth, and reproduction slow or stop to conserve energy.
mTOR can be inhibited by a lack of nutrients or the drug rapamycin.
What is AMPK?
AMP-activated protein kinase is an enzyme. AMPK stimulates mitochondrial biogenesis - the creation of new more efficient mitochondria, which produce more ATP and improve cellular energy. This process also prompts the body to generate glucose in the liver and release energy from fat cells.
AMPK can be activated by exercise or the drug rapamycin.